The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
He was one of the most famous stars of the 80s, who surprised the audience not only with his acting but also with his dancing
As a youth, he had a deep interest for flying, but he surprised both himself and others by pursuing a completely different career path.
He talked on the significance of his wife to him and grieved her passing twenty-eight years after they were married.
After a great deal of tragedy, he is content with his kids and his life right now.
The father of this young kid was a tire shop owner and semi-professional football player who grew up in New Jersey. The young man, however, had little interest in pursuing either as a career.
Rather, he had assumed he would work at the airport as a ticket agent or luggage handler, having developed an interest in the field when his high school offered an aviation program. He did not, however, wind up in the aircraft industry.
He now acknowledges that he has never been patient, claiming that he lacked patience as a youngster, a teenager, and an adult. He revealed:
“Tell me to do something else if I hit 25 and I’m not making a mark in this business,” was my type of man.
The young man chose to try acting, much like his mother had done, rather than following in his father’s footsteps or continuing his love of aviation, which he had discovered at the age of fifteen.
Travolta John Grieving Kelly Preston
The young guy in question is John Travolta, who made his Hollywood debut at the age of eighteen. Throughout his career, he starred in numerous hit films, including “Grease,” “Look Who’s Talking,” and “Saturday Night Fever.”
He met Kelly Preston, a fellow actor, during a screen test for a show called “The Experts,” and the two married during his career. Preston disclosed that she was unfaithful to her spouse during the time.
Preston and Travolta first crossed paths in 1989, and by 1991, Travolta had proposed to Preston. Nine months after Travolta’s proposal, the pair tied the knot and enjoyed a blissful 28-year marriage.
Sadly, Preston’s breast cancer death in 2020 marked the end of their love tale. Travolta, who was heartbroken by the passing, gave fans some advice and said:
“Letting someone experience their grief and not adding to it with your own is the most crucial thing you can do to support them during their time of mourning.”
He claimed that he was feeling constricted by the grief of others over his wife’s death and believed that it was imperative to find a private place to grieve.
These days, Travolta is all about making his kids’ lives better and being there for them as much as he can while they adjust to life without their mother. It is a loving parent he is.
How Does Travolta’s Life Currently Stand?
Two years after his wife’s death, Travolta spent Father’s Day with his kids this year. He posted a picture of himself on Facebook with his son, daughter, and dog curled up on the couch. He continued by wishing a happy Father’s Day to all of the “dedicated fathers.”
His admirers showered him with love and support in the comments, praising him as a fantastic father and expressing how nice it is to see him with his kids.
Travolta and Preston raised a lovely family, but they also suffered a great loss when their son passed away while on vacation in the Bahamas. Travolta is a fantastic parent to his two children right now, despite the sadness he has experienced throughout his life.
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