A girl waves to the train that passes by every day. Three years later, the train driver sees a poster on the window

When was the last time you showed kindness to an unknown individual?Even if you believe that this is a pointless question and that you shouldn’t bother trying to help someone you don’t even know, keep in mind that doing good is always worthwhile.Behaving kindly toward others, even complete strangers you see on a daily basis, has a greater positive impact on their life than you may realize.Furthermore, you never know who among those total strangers will stick around and end up playing a significant role in your life.The tale, shared on the Facebook page *Love What Matters* by Briana Hefley Shepard, describes the peculiar bond that developed between a small girl named Rio and the train conductors who were eagerly awaiting her greeting from their enormous window.Your heart will melt at this story.Ensure that you finish reading the story.About three years ago, our company relocated to the new site.Because of its proximity to the railroad lines, we have a front-row seat to observe all the locomotive activity.The workers quickly noticed Rio extending a greeting to them, and they returned the kind.

They made it into a ritual over time.They let out a whistle, she hurried to the window, they opened their windows, and all of them grinned broadly.Almost every time, I would cry. Then Rio began attending school a few weeks ago.I was impacted by her daycare adjustment a bit more than I had anticipated, but more on the first day when the train passed and she wasn’t present.They opened their windows and whistled, but I was the only one crying and hesitantly waving.Next day, I created a placard.All I wrote was, “She started school.”When I heard the whistle, I hurried to the window and waved my placard.That was three weeks ago. “Oh, I shed a tear.”

Someone knocked on the door this morning, nearly minutes after I entered the store.It was a dude with earbuds hanging down who was wearing a bright yellow t-shirt.Because that’s what we do here, I assumed it was a construction worker who wanted to discuss construction-related topics.I was in error. He had come to inquire about the blonde girl who was greeting the trains.Everyone was curious about her whereabouts as she was an employee.They stopped higher up the tracks, came to our building, and knocked on our door because they had a short train today.Oh, I did cry.Despite having seen my placard, they were unable to read what it said.

Though they had to double check, they had believed she had started school.Her greetings, he added, brightened their day.For three years, they had shared these times together. They miss her and want to do something for her.When they inquired about sending her something, I answered, “Of course!”In a few weeks, they will send her a birthday present.Throughout the past few years, it has been nothing short of miraculous to see their unusual bond.I feel optimism and love knowing that they have been impacted just as much as we have.My faith in mankind and goodness has been reinforced by their presence today and their ongoing generosity to Rio.These are the times we shall never forget.

We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth

The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.

A dental breakthrough

While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.

A bit of science

The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.

As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.

On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.

BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.

“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.

The first results

Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.

“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.

Fully regrown frontal teeth in ferrets

The next steps

Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontiaa genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.

Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.

“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”

So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.

Preview photo credit KyotoU_News / Twitter

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