Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
High fever Excessive night sweats Extreme fatigue Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
Severe swelling in lymph nodes (especially in the neck) CT scan abnormalities indicating TB inflammation Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
Severe chills and fever Uncontrollable night sweats Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
High-dose intravenous (IV) steroids for five days to calm the immune system A slow transition to oral steroids for three months Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot. Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications. Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
Myocarditis (heart muscle inflammation) Pericarditis (inflammation around the heart lining) Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
My Husband Died in an Accident, but I Never Saw His Body — One Day, I Heard His Voice Coming from Our Little Daughter’s Bedroom
Grief plays tricks on the mind, but this? This was real. Kelly knew her husband’s voice, and she’d just heard it… coming from her daughter’s room. A chill ran down her spine. Jeremy had been dead for two years. So who — or what — was speaking in his voice? Then she stepped inside… and FROZE.
I’m Kelly. I’m 30, and my life has been a rollercoaster of love and loss. My husband, Jeremy, died in a car accident two years ago. I was eight months pregnant with our daughter, Sophia. One moment, I was painting flowers on the walls of her nursery, dreaming about our future. The next, I was getting a phone call that shattered my world.
A pregnant woman looking at her phone | Source: Pexels
I remember that moment like it was yesterday. The paintbrush slipped from my fingers, leaving a trail of pink down the wall.
“Miss Kelly?” the voice on the phone was gentle, practiced. “This is Officer Reynolds…”
“Yes?” My hand instinctively went to my swollen belly. Sophia kicked, as if sensing my fear.
“There’s been an accident. Your husband…”
“No,” I whispered. “No, please…”
A startled woman talking on the phone | Source: Midjourney
They told me the crash was bad — so bad that I shouldn’t see his body. I never got to say goodbye. Just a closed casket at the funeral, and that was it.
“Kelly, honey,” my mom had said at the funeral, holding me as I sobbed. “You need to stay strong. For the baby.”
“How?” I choked out. “How am I supposed to do this without him? He was supposed to be here. He was supposed to hold her…”
Men carrying a coffin | Source: Pexels
Two years later, I was doing my best to keep going, to be strong for Sophia. But the emptiness? It never really left.
And then, two days ago, something happened that made me question everything.
It was just a regular afternoon. I had put Sophia down for her nap in her bedroom and curled up on the couch with a book. The house was quiet. Peaceful.
Until I heard it.
The sound of a window shutting. Not loud — just enough to make me glance up. Probably the wind, I thought. But then, my blood ran cold when I… Oh my God… when I heard JEREMY’S VOICE:
“I love you forever.”
I swear to God, my whole body turned to ice.
It wasn’t a muffled memory in my head. It wasn’t wishful thinking. It was CLEAR AS DAY.
A terrified woman | Source: Midjourney
I sat frozen, my breath caught in my throat. My ears were ringing. My heart pounded so hard I thought I might pass out.
“Jeremy?” I whispered into the silence, my voice trembling. “Baby, is that you?”
No. No, no, no. Jeremy was gone. This was NOT POSSIBLE.
But I heard it. Again.
“I love you forever.”
It was coming from Sophia’s room.
A frantic woman standing at the doorway | Source: Midjourney
I shot up so fast the book tumbled off my lap. My mind raced with possibilities — was someone in there? Was I hallucinating?
Was Jeremy ALIVE?
I rushed down the hallway, barely feeling my feet hit the floor. My hands were ice-cold, and my stomach churned like I might throw up.
“Please,” I whispered as I ran, tears already forming. “Please, if you’re there…”
I pushed open Sophia’s door.
A terrified woman walking into a room | Source: Midjourney
She was sound asleep in her crib, curled up in a little ball, her tiny fingers clutching a teddy bear. The room was just as I had left it. No open windows. No shadows in the corner. Nothing.
But then, I heard it again.
“I love you forever.”
I swore my heart stopped.
“Jeremy?” My voice cracked. “Is this some kind of cruel joke? Please… I can’t… I can’t take this…”
I scanned the room, my hands shaking as I moved toward the window. Something had to explain this.
A little girl fast asleep while holding a teddy bear | Source: Midjourney
My fingers brushed against the glass. It was shut. Locked. Outside, a small tree branch rested against the pane, broken like it had fallen against it.
Okay. That explained the noise. But Jeremy’s voice?
My eyes darted back to Sophia. She stirred in her sleep, hugging the bear tighter.
“Dada,” she murmured in her sleep, and my heart shattered all over again.
And then it hit me.
The bear.
I dropped to my knees beside her crib, hands trembling as I reached for it. Pressed it.
“I love you forever.”
My chest squeezed so tight I thought I might collapse.
A startled woman holding a teddy bear | Source: Midjourney
Jeremy’s voice… It was coming from the bear.
“Oh God,” I sobbed, clutching the bear to my chest. “Oh God, Jeremy…”
I sat on the couch, staring at the bear like it might come to life.
I had no memory of buying this. Had someone given it to Sophia?
And then I remembered. A week ago, we had celebrated Sophia’s second birthday. My mother-in-law, Gloria, had given her this bear.
A little girl celebrating her 2nd birthday | Source: Pexels
“Look what Grandma got you!” I had said, trying to sound cheerful despite the ache in my chest. Another birthday without Jeremy.
I had barely looked at it at the time. It was just another stuffed animal.
But now? Now I needed answers. So I called Gloria.
She picked up on the second ring. “Kelly, hi, sweetie! Everything okay?”
An older woman holding her phone | Source: Midjourney
I gripped the bear tighter. “Did you know this thing plays Jeremy’s voice?”
Silence.
Then, a quiet, almost hesitant, “Oh… did it finally play?”
My stomach twisted. “Finally? What do you mean FINALLY?”
Gloria sighed. “I was wondering when you’d hear it.”
I sat up straighter. “Gloria. What did you do?”
A woman talking on the phone | Source: Midjourney
“Kelly, please,” her voice wavered. “Just let me explain…”
“Explain what?” I demanded, my voice rising. “Explain why you thought it was okay to… to…”
I couldn’t even finish the sentence.
Gloria showed up an hour later, looking almost nervous. She sat across from me, hands folded, eyes scanning my face.
“I just… I thought it would help,” she said softly.
I placed the bear between us. “Help who?”
Two women talking to each other | Source: Midjourney
She exhaled. “Sophia. And you.”
I stared at her.
“Kelly,” she reached across the table, taking my hand. “Every time Sophia asks about her daddy… every time I see you trying to explain… it breaks my heart.”
“And you don’t think this breaks mine?” My voice cracked. “To hear his voice again, out of nowhere?”
Gloria swallowed. “After Jeremy died, I kept thinking about how Sophia would never know her dad’s voice. So I took a recording from your wedding video. You remember his vows?”
My throat closed.
“‘I love you forever,'” she whispered.
Oh my God.
A woman overwhelmed with emotions | Source: Midjourney
“I remember,” I choked out. “He… he practiced those vows for weeks. Said he had to get them perfect…”
She clasped her hands together. “I had it sewn into the bear before her birthday. I wanted her to have a piece of him. To know he’s always with her.”
I blinked hard, staring at the table, my mind spinning.
She had meant well. I knew that. But I felt so blindsided.
“Gloria,” I said, my voice barely above a whisper. “You should have told me.”
“I know,” she admitted with a fragile smile. “I just… I didn’t want to upset you.”
An older woman smiling | Source: Midjourney
“Upset me?” I laughed bitterly. “I thought I was going crazy. I thought… for a moment, I thought he was…”
“Alive?” Gloria finished softly. “Oh, sweetheart…”
She moved around the table, pulling me into her arms as I broke down.
“I miss him so much,” I sobbed. “Every single day…”
“I know,” she stroked my hair. “He would be so proud of you, Kelly. So proud of how you’re raising Sophia.”
I didn’t know what to say.
I wasn’t angry. I wasn’t relieved. I was just… overwhelmed.
A distressed woman | Source: Midjourney
That night, I sat in Sophia’s room, watching her sleep. The bear was in my lap. My fingers traced the soft fabric as I stared at my little girl — the daughter Jeremy never got to meet.
She looked so much like him. The same curve to her nose, the same dimple when she smiled, and the same sparkling blue eyes.
“You would have loved her so much,” I whispered into the darkness. “She’s perfect, Jeremy. Just perfect.”
I pressed the bear one last time as a familiar voice filled the room and my heart:
“I love you forever.”
A lump formed in my throat. I wiped my eyes quickly, swallowing down the ache.
I missed him.
A heartbroken woman holding a teddy bear | Source: Midjourney
Sophia stirred, her eyes fluttering open. “Mama?”
“Hey, baby girl,” I whispered, reaching to stroke her cheek.
“Bear?” She reached for the teddy.
I handed it to her, watching as she pressed it to her chest. Jeremy’s voice filled the room again.
“That’s your daddy,” I told her, my voice thick with tears. “He loves you so, so much.”
A cheerful little girl holding a teddy bear | Source: Midjourney
“Dada?” She looked at the bear with wide eyes, then back at me.
“Yes, sweetheart. That’s Dada.”
She hugged the bear tighter, closing her eyes. “Love Dada.”
And for so long, I thought I had lost everything. But here, in my daughter’s arms, was a piece of him.
I leaned down and kissed Sophia’s forehead.
“You’ll always have him with you, my sweet girl,” I whispered. “Always.”
The grief was still there. It always would be.
But for the first time in a long, long time… I didn’t feel so alone.
A grieving woman holding herself together | Source: Midjourney
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